Epicrates cenchria is found in lower Central America (Costa Rica and Panama), and farther south into South America it occurs east of the Andes roughly reaching northern Argentina
In the wild, their diet consists of rodents, birds and possibly some forms of aquatic life and lizards.
Rainbow boas are nocturnal and most active in the middle of the night. This species is semi-arboreal, spending time both on the ground and in trees. They are also known to spend time in bodies of water, and are considered capable swimmers.